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Biovillage: Kawasan Berkonsep Zero Waste

bu enung

Dr. Enung Sri Mulyaningsih merupakan salah seorang peneliti di Pusat Penelitian Bioteknologi-LIPI yang dipercaya menjadi koordinator sasaran kegiatan program biovillage sejak tahun 2016. Dari program yang dirancang sampai tahun 2019 ini, terdapat harapan-harapan besar yang dititipkan pada sosok yang dikenal ramah serta cerdas ini. Berikut adalah petikan wawancara yang telah dilakukan oleh tim humas Pusat Penelitian Bioteknologi - LIPI seputar program biovillage dengan koordinator sasaran kegiatan biovillage:

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Biovillage: Wahana Rekreasi IPTEK Hayati Bagi Masyarakat Indonesia

deputi iph

(Bersama Kepala Deputi bidang IPH LIPI)

Biovillage merupakan salah satu program unggulan Kedeputian Ilmu Pengetahuan Hayati Lembaga Ilmu Pengetahuan Indonesia (LIPI) yang dibangun sejak tahun 2015, dan merupakan etalase hasil penelitian yang berada di kawasan Cibinong Science Center Botanic Garden (CSC-BG), Kabupaten Bogor.

Untuk menggali informasi lebih lanjut mengenai program Biovillage, Tim Humas Pusat Penelitian Bioteknologi -LIPI berkesempatan mewawancara Deputi Ilmu Pengetahuan Hayati - LIPI, Prof. Dr. Enny Sudarmonowati, berikut petikannya:

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Biovillage: Etalase Paket Teknologi Hayati

kapus

Biovillage merupakan salah satu program unggulan Kedeputian Ilmu Pengetahuan Hayati Lembaga Ilmu Pengetahuan Indonesia (LIPI) yang dibangun sejak tahun 2015, dan merupakan etalase hasil penelitian yang berada di kawasan Cibinong Science Center Botanic Garden (CSCBG), Kabupaten Bogor. Untuk menggali informasi lebih lanjut mengenai program Biovillage, Tim Humas Pusat Penelitian Bioteknologi-LIPI berkesempatan mewawancara Kepala Pusat Penelitian Bioteknologi - LIPI, Dr. Bambang Sunarko, berikut petikannya:

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Removing a Cystein Group On Interferon Alpha 2b at Position 2 and 99 does Not Diminish Antitumor Activity of the Protein, Even Better

Heni Rachmawati, Adhitya Jessica, Yeyet Cahyati Sumirtaputra, Debbie Sofie Retnoningrum, Amirah Adlia, Ratih Asmana Ningrum (2016).

Removing a CysteinRemoving a Cystein Group On Interferon Alpha 2b at Position 2 and 99 does Not Diminish Antitumor Activity of the Protein Even Better Group On Interferon Alpha 2b at Position 2 and 99 does Not Diminish Antitumor Activity of the Protein, Even Better.

Scientia Pharmaceutica. 84: 113–130. ISSN 0036-8709 (Print) ISSN 2218-0532 (Online) ISSN-L 0036-8709

Interferon alpha 2b is the only standard therapeutic protein for hepatitis virus infections. Further study demonstrated that this protein also posseses antitumor activity in several cancerous organs. One main pathway of this antitumor activity is mediated through antiproliferation as well as proapoptotic effects. Previously, we have successfully developed recombinant human interferon alpha 2b (rhIFNá2b) by using a synthetic gene. In addition, two mutein forms of rhIFNá2b were generated to improve the characteristics of this protein. Two point mutations showed better pharmacokinetic profiles than one point mutation as well as the native form. In the present study, this mutein form was studied for ist antitumor effect in vitro using HepG2 cells. As a comparison, the native form as well as a commercial rIFNá2b were used. Several parameters were investigated including the MTT assay, cell viability test, cell cycle using flow cytometric analysis, and the genes and protein expressions involved in cell growth. The latest was observed to study the mechanism of rhIFNá2b. There was no significant difference in the MTT assay and cell viability after cells were treated with both forms of rhIFNá2b. However, the mutein rhIFNá2b tended to show better proapoptotic activity reflected by flow cytometric data, protein expression of pSTAT1, and DNA expression of caspase 3.

Keywords: Interferon alpha 2b, Antiproliferation, Apoptosis, p21k1, p27, Caspase 3, pSTAT1, Flow cytometri, Mutein

Sumber: http://perpus.biotek.lipi.go.id/index.php?p=fstream&fid=3022&bid=15484

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